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Valganciclovir
Identification
DCI
valganciclovir
Code ATC
J05AB14
PubChem
64147
Propriétés chimiques
Formule brute
C14H22N6O5
Masse molaire[1]
354,3617 ± 0,0154 g/mol C 47,45 %, H 6,26 %, N 23,72 %, O 22,57 %,
Unités du SI et CNTP, sauf indication contraire.
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Le valganciclovir est un médicament antiviral agissant comme une prodrogue. Donné par voie orale, il est transformé en ganciclovir qui est la molécule active, ciblant le cytomégalovirus.
Sommaire
1Pharmacocinétique
2Efficacité
3Effets secondaires
4Notes et références
Pharmacocinétique |
La biodisponibilité est d'environ 40 %[2].
Efficacité |
Chez le nouveau-né, il permet de traiter l'infection congénitale à cytomégalovirus, contribuant à améliorer les conséquences sur l'audition. Un traitement plus prolongé (six mois) semble améliorer le neurodéveloppement de l'enfant[3].
Effets secondaires |
Il existe une chute des polynucléaires neutrophiles (neutropénie) dans plus d'un tiers des cas[2].
Notes et références |
↑ Masse molaire calculée d’après « Atomic weights of the elements 2007 », sur www.chem.qmul.ac.uk.
↑ a et b(en) Kimberlin DW, Acosta EP, Sanchez PJ et al. « Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus disease » J Infect Dis, 2008;197:836-845.
↑ (en) Kimberlin DW, Jester PM, Sánchez PJ et al. « Valganciclovir for symptomatic congenital cytomegalovirus disease » N Engl J Med, 2015;372:933-943.
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powerbi dax powerbi-embedded
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edited Jun 11 '18 at 20:11
Oleg
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python linux bash
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edited Nov 21 at 22:22
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